Uses and ecology[ edit ] The well-known caper is a pickled flower bud of Capparis spinosa. Caperbushes are mainly used by humans for their fruit, which are rich in micronutrients. The fruit of other species , such as karir C. Mabinlang seeds C. Mabinlang is also used in Traditional Chinese Medicine. Aspalathos, the root of a shrub contained for example in the sacred Ancient Egyptian incense kp.
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E-mail: moc. This article has been cited by other articles in PMC. Abstract The antidiarrheal activity of the methanolic extract of the leaves of Capparis zeylanica Capparidaceae was investigated by castor oil-induced diarrhea and small intestine transit method on mice. The percentage protection in extract-treated animals showing diarrhea was compared with castor oil-treated and loperamide-treated animals.
The activity was found to be dose-dependant. Its effect when evaluated on intestinal transit produced a decrease in intestinal transit The results revealed that the methanolic extract significantly reduced diarrhea in mice with reduction in weight of stools. It is often accompanied by stomach pains, feeling sick and vomiting. It is usually due to consumption of drinking water contaminated with bacteria, undercooked meat and eggs or inadequate kitchen hygiene-in other words-an infection.
According to WHO estimates for , about 7. The genus Capparis L. Capparaceae consists of about species distributed mostly in tropical and subtropical regions. Capparis zeylanica, a rigid, wiry and much-branched shrub, is widely distributed in Bangladesh, India, Sri Lanka and Malaysia.
The plant grows in a moist habitat. It is used traditionally as stomachic, sedative, antihydrotic and also in cholera, hemiplegia, neuralgia and rheumatism. Hence the methanolic extract of C.
The plant has previously been reported to produce fatty acids. A voucher specimen no. Leaves were dried in shade for 20 days and then powdered to get a coarse powder. This powder was stored in air-tight container and used for further successive extraction. Preparation of Crude Extract The dried and powdered plant material was soxhlet extracted with methanol. The extraction was carried out for 24 h at room temperature with mild shaking.
The percentage yield of methanolic extract was found to be They were fed with commercial pellet diet and water ad libitum. D Fine chemicals, Mumbai , normal saline solution 0. Acute Toxicity Study The method previously described by Lorke was adopted using 13 mice.
In the second phase, more specific doses were administered to four groups each containing one mouse. Castor Oil-induced Diarrhea Twenty-four mice were allowed to fast for 18 h and divided into five groups of six animals each. All groups received castor oil at a dose of 0. Thirty minutes after castor oil administration, the first group control group received vehicle 0. After the administration, the animals were placed separately.
The severity of diarrhea was assessed each hour for 6 h [ Table 1 ]. The total weight of feces was recorded within a period of 24 h and compared with the control group.
The results were expressed as a percentage of inhibition of diarrhea. Group V received atropine sulphate 0. After 30 min animals were killed by cervical dislocation, and the intestine was removed without stretching and placed lengthwise on moist filter paper.
The length of the intestine pyloric sphincter to cecum and the distance travelled by the charcoal as a percentage of that length were evaluated for each animal, and group means were compared and expressed as percentage inhibition. Castor oil causes diarrhea due to its active metabolite, ricinolic acid,[ 23 , 24 ] which stimulates peristaltic activity in the small intestine, leading to changes in the electrolyte permeability of the intestinal mucosa.
Its action also stimulates the release of endogenous prostaglandin. Its effect was dose-dependant. The antidiarrheal activity of this extract may also be due to the presence of denatured proteins, which form protein tannates. Protein tannates make the intestinal mucosa more resistant and hence, reduce secretion.
Loperamide, apart from regulating the gastrointestinal tract, is also reported to slow down transit in the small intestine, reduce colon flow rate, and consequently any effect on colonic motility. The study reveals that the methanol extract exhibited significant diarrheal activity. Thus, C. In conclusion, the results of this investigation revealed that C.
These properties confirm the use of C. Further research is to be carried out to fractionate and purify the extract, in order to find out the molecules responsible for the antidiarrheal activity observed. Footnotes Conflict of Interest: Nil. Etiology and epidemiology of diarrhoea. Phillips J Microbiol Infect Dis. Lutterodt GD.
Inhibition of gastrointestinal release of acetyl choline by quercetin as possible mode of action of psidium guajava leaf extracts in the treatment of acute diarrhoeal disease. J Ethnopharmacol. Park K. Ojewole JA. Evaluation of the antidiabetic, anti infl ammatory and antidiabetic properties of sclerocarya birrea A. Phytother Res. In: Pharmacognosy. London: Bailliere Tindal; London: L. Reeve and Co. Ltd; Duke JA. Maryland, USA: New York: John Wiley; Biswas K, Ghosh E. In: Bharotyo Banoushodhi 1.
Calcutta: University Press; Indian Eng Chem Res. Evaluation of Capparis deciduas for Anthelmintic and Antimicrobial activities. Indian J Nat Prod. Anti inflammatory and analgesic activity of Capparis zeylanica root extracts. Chopra RN. Glossary of Indian Medicinal Plants. Indian Medicinal Plants. Dehradun, India: Oriental Enterprises; E-octadecen-ynoic acid from the roots of Capparis zeylanica.
Sharaf MA. Flavonoids of four Cleome and three Capparis species. Biochem Syst Ecol. Mukaherjee PK. Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol. Iwao I, Terada Y. On the mechanism of diarrhoea due to castor oil. Jpn J Pharmacol. Vogel HG. Drug discovery and evaluation-pharmacological assays. New York: Springer; Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats.
J Nat Med. Effects of oleic and recinoleic acids net jejunal water and electrolyte movement. J Clin Investig. Watson WC, Gordon R. Studies on the digestion absorption and metabolism of castor oil. Biochem Pharmacol. Antidiarrhoeic activity of Scleroarya birrea bark extract and its active tannin constituent in rats.
Capparis Zeylanica Herb Uses, Benefits, Cures, Side Effects, Nutrients