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Results The results showed that Standard methods and interpretation criteria need to be established. Peer Review reports Background Lung cancer is one of the leading causes of cancer-related deaths in the world. Given the low response rate, the identification of the patients who are most likely to derive clinical benefit from EGFR-targeted therapy is important [ 1 — 6 ].

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Bar-Sagi has published over peer-reviewed articles in leading scientific journals. His main research interests include the molecular mechanisms of mammalian cell-cycle control and responses to DNA damage, and the cancer-predisposing aberrations of these regulatory pathways.

Jiri Bartek has a total of more than publications in peer reviewed journals about in Nature, Science and Cell , with over He is currently member of the editorial boards of 10 high-medium impact biomedical journals and has won a number of awards including: , Czech Medical Association Award, Elected EMBO member, A.

Baylin, M. Stephen B. Baylin is professor of oncology and medicine, director of the cancer biology program at the oncology center, and the Virginia and D. For the last 20 years, Dr. Baylin has studied the role of epigenetic gene silencing in the initiation and progression of human cancer. Joseph R. Bertino, M. From to , Dr. Bertino served as director of the Yale Comprehensive Cancer Center, including director of the center and associate director for clinical research.

Bertino has been internationally recognized for his role in finding curative treatments for leukemia and lymphoma. He was the founding editor of the Journal of Clinical Oncology. Currently, he is the associate editor for Cancer Research and Clinical Cancer Research and also the editor of the Encyclopedia of Cancer. Bertino served as president for the American Society of Clinical Oncology in , and president of the American Association for Cancer Research in Bertino is the author and co-author of more than scientific publications.

Mina J. Bissell, PhD, member of the National Academy of Sciences, Distinguished Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkley, CA Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix ECM and the nucleus environment to gene expression in normal and malignant tissues.

These works have ushered and have changed some central paradigms that have strengthened the importance of context in the development of cancer. Blazar, M. Cowan has authored more than papers for scientific journals and has been appointed by President Bush to a six-year term on the National Cancer Advisory Board to help shape cancer policy.

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Received Nov 15; Accepted Jun This article has been cited by other articles in PMC. Abstract Background Despite the large number of published papers analyzing the prognostic role of Ki in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis summarizes and analyses the associations between Ki expression and clinical outcome in NSCLC patients. Methods PubMed, Cochrane, and Embase databases were searched systematically using identical search strategies. Results In total, 32 studies from 30 articles met the inclusion criteria, involving patients. Additionally, while high expression was more common in males, smokers, and those with poorer differentiation, there was no correlation between high Ki expression and age or lymph node status.

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Bar-Sagi has published over peer-reviewed articles in leading scientific journals. His main research interests include the molecular mechanisms of mammalian cell-cycle control and responses to DNA damage, and the cancer-predisposing aberrations of these regulatory pathways. Jiri Bartek has a total of more than publications in peer reviewed journals about in Nature, Science and Cell , with over He is currently member of the editorial boards of 10 high-medium impact biomedical journals and has won a number of awards including: , Czech Medical Association Award, Elected EMBO member, A. Baylin, M. Stephen B. Baylin is professor of oncology and medicine, director of the cancer biology program at the oncology center, and the Virginia and D.

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Anal Bioanal Chem. The development and application of advanced proteomics technology and new experimental models has created unique opportunities for translational studies. In this study, we investigated the ovarian cancer proteome of the chicken, an emerging experimental model of OVC that develops ovarian tumors spontaneously. Matched plasma, ovary, and oviduct tissue biospecimens derived from healthy, early-stage OVC, and late-stage OVC birds were quantitatively characterized by label-free proteomics. Collectively, these data provide the first evidence for involvement of OVOS2 in the pathogenesis of both chicken and human ovarian cancer. Interleukin enhances breast cancer cell migration via down-regulation of claudin and induction of the p38 MAPK pathway. Biochem Biophys Res Commun.

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